核苷酸

四活物

如图二 (a) 所示: DNA分子中核苷酸的 “碱基” 有四种形式:

A,  T, C, G.

如图三 (a) 所示: 四活物的 “脸” 也有四种形式:

鹰, 牛, 人, 狮.

如图二 (b) 所示: 核苷酸的 “糖”只含有

五个碳原子

如图三 (b) 所示: “人的手” 都是 

“五指” 结构

如图二 (c) 所示: 结晶纯磷的外观与极象

“黄铜”

如图三 (c) 所示: 四活物的 “脚” 如光明的

“铜”.

核苷酸附属的四个化学键

“四活物” 的四个 “翅膀”

有两个3’-5’连接键

与上下两个相邻的核苷酸相互连接

各展开上边的两个翅膀相接

翅膀彼此相接

有两个氢键

与互补碱基并联

各以下边的两个翅膀

遮体

In 1953 Watson and Crick described the “four nucleotides”

2600 years ago Ezekiel described the “four living creatures”

1

four nitrogenous base

A, T, C, G

had four faces

2

sugar

Five-carbon sugar

they had the hands of a man (five fingers)

3

Phosphate

pure phophruos likes the “color of burnished brass”

their feet “like the color of burnished brass”

4

Four linkages:

·   Two 3’5’ linkages

·   two hydrogen bounds between the bases

every one had four wings:

·   two wings were joined one to another

·   and two covered their bodies

Chapter: Verse

Ezekiel Code (KJV, in metaphor words)

Annotate (in common words)

DNA molecule (in biological terminological words)

1

1:4

a whirlwind came out of the north, … Also out of the midst thereof came the likeness of four living creatures …   they had the likeness of a man.

Overview of the thing included four characters

DNA, the right-handed double helical molecule that composed by four kinds of nucleotides encoding the human biological body.

2

1:4

 whirlwind

Helix thing

Double helical long-chain

3

1:4

came out of the north

Tornado spin direction is right-handed helical on north hemisphere

DNA spin direction is right-handed helical

4

1:4

a fire infolding itself

Energy releasing

Energy releasing are necessary when enzymes working on DNA

5

1:4

colour of amber, out of the midst of the fire.

Thing emits strong white light

Magnesium in enzymes. Strong white light as burning reaction of magnesium.

6

1:5

four living creatures

only four things there

There are only four kinds of nucleotides in DNA

7

the likeness of a man.

Constituting the form of mankind

DNA information encoding the human biological body

8

1:6

four faces

Four structure as identity card

Four nitrogenous base are nucleotides’ identity in DNA

9

1:6

 wings

Expanding things from body to outside

Chemical bonds between nucleotides

10

1:7

calf's foot: and they sparkled like the colour of burnished brass.

Yellow material

A phosphate in phosphate acid in each nucleotide. Crystal phosphate is yellow.

11

1:8

they had the hands

There are five-structure thing in

A deoxyribose (five-carbon structure) in each nucleotide

12

1:9

Their wings were joined one to another;

Linker between things

The chemical bonds between the phosphates and the sugars to form sugar-phosphate backbone for linking one nucleotide to the next in the DNA strand

13

1:10

four faces: man, lion, ox ,eagle

Four individual’s identities

Four nitrogenous base as nucleotides’ identity in DNA: adenine (A), thymine (T), Cytosine (C) and gunine (G)

14

1:10

Face of ox

Close related on calf

Cytosine was first discovered in 1894 from calf thymus tissues.

15

1:10

Face of eagle

Close related on birds

The first isolation of guanine was in 1844 from birds

16

1:11

 two wings covered their bodies.

Expanding things for cover, protection, maintain its main structures

Hydrogen bonds between complementary nucleotides (A-T, C-G), responsible for establishing and preserving DNA’s special structure and functions, such as, 1. The bases are largely buried in the interior of the DNA and are kept away from water. 2. Two chains are held together to form double helix. 3. Hydrogen bonds of complementary nucleotides, A-T (two bonds), C-G (three bonds), assure the proper sequence of each daughter DNA strand during DNA replication (semiconservative model of replication). It was very appropriate that the three special functions of the hydrogen bonds were summarized as “covering its body”.

17

1:12

And they went every one straight forward: whither the spirit was to go, they went; and they turned not when they went.

fixation of the direction following the guide

nucleotides link in 5’—3’ or 3’—5’ direction in DNA

18

1:13

living creatures, their appearance was like burning coals of fire, and like the appearance of lamps:

Four things carry high energy than common status

Deoxynucleoside triphosphate (dNTP), with more energy than Deoxynucleoside monophosphate (dNMP)

19

1:13

it went up and down among the living creatures

Energy transferring among them

Energy of dNTP are transferred from ATP

20

1:13

out of the fire went forth lightning.

Soon extinguish after movement

When dNTP are assembled into DNA the energy released

21

1:14

the living creatures ran and returned as the appearance of a flash of lightning

Movement very much fast and there are a lot

3 billions nucleotides needed during a DNA molecule formed, 50 nucleotides per second

22

1:15

living creatures, behold one wheel

Together with ring-shape thing

Ring-shape proteins working on nucleotides

1:16

the colour of a beryl:

?

23

1:16

a wheel in the middle of a wheel.

Multiple wheel shape things combine together

ring-shape protein with multiple subunits  together

1:17

When they went, they went upon their four sides: and they turned not when they went.

Same with 17

Same with 17

24

1:18

their rings, they were so high that they were dreadful;

Very bigger than living things

Multiple subunits ring-shape proteins is larger than nucleotides

25

1:18

their rings were full of eyes round about them four

With very complex structure on it

Multiple subunits ring-shape proteins are very complex structure with binding sites

26

1:19

when the living creatures went, the wheels went by them: living creatures were lifted up from the earth, the wheels were lifted up

Activation must be together, depended each other

Structural of helicases has been identified to assemble into multisubunit ring-shaped hexamers. In most, hexamer formation requires nucleotide binding.

27

1:20

for the spirit of the living creature was in the wheels.

The living things are controlled completely by wheel shape thing

The hexmer-ring cannot be formed and not move on DNA (either 5’ to 3’ or 3’ to 5’direction) without binding NTP because the helicases are NTP-driven motor proteins.

1:21

Same with 1:20

Same with 27

Same with 27

28

1:22

And the likeness of the firmament upon the heads of the living creature was as the color of the terrible crystal, stretched forth over their heads above.

A special structure over the above that with crystal structure

The membrane architecture is a lipid bilayer and proteins embedded in the bilayer. The structure of membrane looked like “ice” or “crystal” from cytoplasm toward outside.

1:23

Same with 1:9 and 1:11

Same with 16

Same with 16

29

1:24

And when they went, I heard the noise of their wings, like the noise of great waters

All activation are occurring in water

The “space” inside of cell under the membrane called “cytoplasm”. The entire cell including nucleus is full of water and also the enzyme-catalyzed reactions take place in aqueous solutions.

30

1:25

And there was a voice from the firmament that was over their heads, when they stood, and had let down their wings.

All activation are controlled by a signal system

The reactions of replication, transcription and translation are controlled by the molecular signals.

1:26

?

1:27

?

31

1:28

appearance of the bow

Light with water existing in the same space and same time

During these reactions the water-generated and energy-released in the same time

32

1:28

the day of rain

water formation

During these reactions the water-generated

33

2:9

a scroll

A roll- ship thing that contained series of information.

Human DNA molecule twines into “rolls” of chromosomes, the information of genomic DNA is a huge “book” formed many years ago not by humankind. The genome includes about 35 thousands genes (sentences).

34

2:10

he unrolled before me

Humankind cannot “open” and read it directly.

Humankind cannot “open” and read DNA directly.

35

2:10

on both sides

Two sides.

Two strands of DNA, one is up side another is down side.

36

2:10

were written words

Express information by unites.

Nucleotides, A, T, C, and G, or genes.

37

2:10

lament and mourning and woe

basic behaviors and emotions

Genomic DNA determine human basic behaviors and emotions.

38

3:1-3

eat this roll. take the roll as food. I eat it; as honey for sweetness

The roll- ship thing contained series of information can be eaten as food and contains sugar.

The DNA, a unique biological material, certainly can be eaten and contains sugar (pentose sugar), “sweet” indeed.

39

3:5

 a strange speech and of an hard language

A special information system different from human languages.

A genomic DNA is a “book”, the genes are the “words or sentences” to be a chemical language, a special strange language.

40

3:6

Not to many people of a strange speech and of a hard language, whose words thou canst not understand.

Languages that cannot be understand by ancient people. 

Modern scientists use the scientific terminology, parameters and language to understand biological information on genomic DNA.

41

3:6

Surely, had I sent thee to them, they would have hearkened unto thee.

Some one would surely understand the mystery thing Ezekiel saw.

Modern scientists can understand DNA molecule structure and function as Ezekiel saw.